CV Ângela Guerra

 

Ângela Guerra   Estudante de doutoramento                                 Mestre em Bioquímica   Universidade de Évora     Este endereço de email está protegido contra piratas. Necessita ativar o JavaScript para o visualizar.   Tel:+351 284 314 399   Ext. 01023

   

Education and Training

Biochemistry degree, School of Sciences and Technology, University of Évora, Évora, Portugal (2008).

Biochemistry Master degree, School of Sciences and Technology, University of Évora, Évora, Portugal (2011).

Research and Professional Experience

Jul. 2014 (current): PhD student/researcher

CEBAL – Centro de Biotecnologia Agrícola e Agro-alimentar do Baixo Alentejo e Litoral, Beja, Portugal.
CICECO – Center for research in ceramics & composite materials, Aveiro, Portugal.
Project SFRH/BD/98635/2013 - Potential of Eucalyptus spp bark extrac ts as new anti-cancer agents: mechanistic insights into cell function and metabolism

Oct. 2013 - May. 2014: Research fellow

CEBAL – Centro de Biotecnologia Agrícola e Agro-alimentar do Baixo Alentejo e Litoral, Beja, Portugal.
Project PTDC /AGR-FOR/3187/2012 - NEucBark - New Valorization Strategies for Eucalyptus spp. Bark Extracts- Fundação para a Ciência e Tecnologia

Nov. 2011 - Sep. 2013: Research fellow 

CEBAL – Centro de Biotecnologia Agrícola e Agro-alimentar do Baixo Alentejo e Litoral, Beja, Portugal.
Project  AFORE: Forest biorefineries: Added-value from chemicals and polymers by new integrated separation, fractionation and upgrading technologies”. Seventh Framework Programme FP7/2007-2013, FP7: CP-IP 228589-2 AFORE.

Feb 2011 - Nov 2011:  Professional trainee

Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Beja, Portugal
Project  BioEcos - Integrated Valorisation of Biomass (2011-2013), project funded by INALENTEJO; Ref. 705- Politica de Cidades - Redes Urbanas para a Competetividade e Inovação

Oct. 2009 - Oct. 2010: Master trainee

Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Beja, Portugal

Mar. 2008 - Jun. 2008: Curricular trainee

Toxicology and Pharmacology Laboratory, School of Sciences and Technology, University of Évora, Évora, Portugal.

Current interests of research

Metabolomics, Molecular regulation of breast cancer, Bioactive compounds, Triterpenoids, Oncobiology, Vascular remodeling regulation and angiogenic mechanisms

Selected Publications

Papers in peer reviewed journals

Guerra, A.R.; Soares, B; Guerreiro, O; Ramos, P; Oliveira, H; Silvestre, A; Freire, C; Duarte, MF: Anti-tumoral activity of lipophilic Eucalyptus bark extracts, enriched on triterpenic acids, against breast cancer cells. Planta Med 2014; 80 - SL41. DOI: 10.1055/s-0034-1394529

Guerra AR, Neyton S, Duarte MF. Role of triterpenic acids on thrombin regulation and PAR1 signaling. Planta Med 2014; 80 - P1L113. DOI: 10.1055/s-0034-1394770

Ramos P, Guerra AR, Guerreiro  O, Santos S, Oliveira H, Freire C, Rocha S, Silvestre A, Duarte MF. Antitumoral and antioxidant activities of lipophilic and phenolic extracts from Cynara cardunculus L. var. altilis (DC). Planta Med 2014; 80 - P1L16, DOI: 10.1055/s-0034-1394674

Ramos, P.A.B., Santos, S.A.O., Guerra, A.R., Guerreiro, O., Freire, C.S.R., Rocha, S.M., Duarte, M.F., Silvestre, A.J.D. (2014) Phenolic composition and antioxidant activity of different morphological parts of Cynaracardunculus L. var. altilis (DC). Ind. Crops Prod. 61: 460-471; DOI: 10.1016/j.indcrop.2014.07.042

Domingues, R.M.A., Guerra, A.R., Duarte, M., Freire, C.S.R., Neto, C.P., Silva, C.M.S., and Silvestre, A.J.D. Bioactive triterpenic acids: from agroforestry biomass residues, to promising therapeutic tools. Mini-Reviews in Organic Chemistry. 11(3), 382-399(18); DOI: 10.2174/1570193X113106660001

Ramos, P.A.B., Guerra, A.R., Guerreiro, O., Freire, C.S.R., Silva, A.M.S., Duarte, M.F., Silvestre, A.J.D. (2013) Lipophilic extracts of cynara cardunculus L. var. altilis (DC): A source of valuable bioactive terpenic compounds. Journal of Agricultural and Food Chemistry 35: 8420-8429; DOI: 10.1021/jf402253a

Ramos, P., Santos, S., Felício, L., Guerreiro, O., Guerra, A., Velez, Z., Jerónimo, E., Martins M.R., Pascoal Neto, C., Silvestre, A.J.D., Duarte, M. (2013),  Valorization of olive mill residues: Antioxidant and breast cancer antiproliferative activities of hydroxytyrosol-rich extracts derived from olive oil by-products. Ind. Crops Prod. 46: 359-368; DOI: 10.1016/j.indcrop.2013.02.020

Mota I, Pinto PCR, Novo C, Sousa G, Guerreiro O, Guerra AR, Duarte MF, and Rodrigues AE. 2013. Eucalyptus globulus bark as source of polyphenolic compounds with biological activity. O PAPEL vol. 74, num. 1, pp. 57 - 64 .

Velez, Z.; Campinho, M.A.; Guerra, A.R.; García, L.; Ramos, P.; Guerreiro, O.; Felício, L.; Schmitt, F.; Duarte, M. (2012) Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities. Agriculture 2, 472-492.

Mota, I., Pinto, P., Novo, C., Sousa, G., Guerreiro, O., Guerra, A., Duarte, M., Rodrigues, A. (2012) Extraction of polyphenolic compounds from Eucalyptus globulus bark: process optimization and screening for biological activity. Ind. Eng. Chem. Res., 51: 6991-7000, DOI: 10.1021/ie300103z

Oral presentations

Guerra, A.R.; Soares, B; Guerreiro, O; Ramos, P; Oliveira, H; Silvestre, A; Freire, C; Duarte, MF: Anti-tumoral activity of lipophilic Eucalyptus bark extracts, enriched on triterpenic acids, against breast cancer cells. 62^nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research. Guimarães, Portugal, 31. August – 4. September 2014.

A Guerra, P Ramos, Z Velez, O Guerreiro, L Guerra, Martins MR, M Duarte “Actividade anti-tumoral de extractos naturais de Cynara cardunculus (cardo) no cancro da mama” I Congresso Nacional de Recursos Silvestres do Mediterrâneo. 13-14 January  2011, Barrancos., Portugal.

Posters in conferences

Guerra AR, Neyton S, Duarte MF. Role of triterpenic acids on thrombin regulation and PAR1 signaling. . 62^nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research. Guimarães, Portugal, 31. August – 4. September 2014.

Ramos P, Guerra AR, Guerreiro  O, Santos S, Oliveira H, Freire C, Rocha S, Silvestre A, Duarte MF. Antitumoral and antioxidant activities of lipophilic and phenolic extracts from Cynara cardunculus L. var. altilis (DC). 62^nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research. Guimarães, Portugal, 31. August – 4. September 2014.

A.R. Guerra, O. Guerreiro, P. Ramo, P. Parreira, H. Oliveira, C. S. R. Freire, A. J. D. Silvestre, M.F. Duarte. Anti-tumoral activity of triterpenic acids on human breast cancer cells. SINAL 2013: 7th National meeting on cell signalling. Universidade de Aveiro, Aveiro, Portugal. Dezembro 6-7, 2013.

A Guerra, O Guerreiro, P Ramos, J Pereira, C Lima, C Pereira-Wilson, H Pereira, R Domingues, AJD Silvestre, MF Duarte “Anti-tumoral activity of lipophilic Eucalyptus bark extracts on human cancer cells”, IX CICECO Meeting, May 2-3, 2012 

Thesis

Guerra AR (2011), Anti-tumoral activity of Cynara cardunculus extracts in the PI3K/AKT/mTOR signaling pathway, Biochemistry Master degree thesis, Universidade de Évora